Dermatology in Practice

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A practical approach to using 5-fluorouracil cream
DIP, Volume 16, Number 1.

In the early 1960s, 5-fluorouracil was developed as an anticancer drug. It is a thymine analogue antimetabolite, which is incorporated into ribonucleic acid (RNA) and inhibits DNA synthesis, ultimately leading to cell death. A patient who was receiving systemic treatment was observed to develop inflammation and then clearing of his actinic keratosis.

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