Study participants reported improvements in scaling, thickness and itching 

New research indicates that intermittent fasting could help to reduce the skin symptoms experienced by patients with psoriasis.

The study, findings from which were presented at the EADV Spring Symposium, showed a significant reduction in scaling and thickness in patients with mild psoriasis following the so-called 5:2 diet (a form of intermittent fasting for which people eat normally for five days and fast for two).

Twenty-four participants were enrolled in the study: one group of 12 modified their diet with intermittent fasting (5:2) for 12 weeks, while the other 12 participants continued on their regular diet. During the trial, two patients were excluded (one because of antibiotic treatment and one due to loss to follow-up).

Objectively, PASI (Psoriasis Area and Severity Index) and Body Surface Area (BSA) did not differ significantly between fasting and regular diet, although PASI was reduced in the fasting group (p<0.05). 

Waist circumference and weight were comparable at six weeks, but reduced significantly in the fasting group at week 12 compared to the control group (p<0.05 and <0.001, respectively). 

Fasting subjects reported significant improvement more frequently at weeks six and 12 (p<0.0001), mentioning less scaling and thickening, with 30% of patients also reporting a decrease in itching. 

"The effect of dietary interventions on skin health is a stimulating field of research in dermatology. The results of this study add to the growing body of evidence being undertaken to understand the relationship between the gut and skin, with some promising results for patients and the disease management of psoriasis," commented Professor Marie-Aleth Richard, EADV Board Member and Professor at the University Hospital of La Timone, Marseille.

The study will be completed at the end of June.