Intended for healthcare professionals

National safety guidelines for oral methotrexate

Rebecca Davis and Megan Dixon
Oral methotrexate is an antimitotic drug that reduces cell division within the body. High doses are prescribed as a cytotoxic agent for certain cancers. Low doses are used for severe psoriasis and some inflammatory skin diseases. It can produce serious side-effects, such as suppression of the immune system. According to the National Patient Safety Agency (NPSA), ‘Oral methotrexate is a safe and effective medication if taken at the right dose and with appropriate monitoring’.
Dermatology in practice 2005; 13(3): 26–27
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